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Introduction Proteins are nature's versatile nanomachines— they have evolved to perform virtually every important task in living systems. While nature has produced an incredible range of protein functions, these represent only a tiny fraction of what's possible in the protein universe. Evolution has only explored
Protein “language” is a lot like human language. Given the similarities, researchers have been building and training language models on protein sequence data, replicating the success seen in other domains, with profound implications. In this post, I will explore how transformer models have been applied to protein data
Lately, I've been experimenting with interfaces for large language models (LLMs) in my free time. The fruit of this labor is something I'm calling "curie," an exploratory and sense-making tool designed to navigate complex topics. 0:00 0:34 1× the limitations of
At the end of this blog post, you will be able to: Describe functional programming concepts Write functional programming code using purrr package in R If you are anything like me, you probably focused primarily on learning statistics, machine learning and programming on a smaller scale early on in your
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Tony Tyson’s cameras revealed the universe’s dark contents. Now, with the Rubin Observatory’s 3.2-billion-pixel camera, he’s ready to study dark matter and dark energy in unprecedented detail. The post The Biggest-Ever Digital Camera Is This Cosmologist’s Magnum Opus first appeared on Quanta Magazine
Some not-actively-discouraging news out of Washington DC yesterday: The Senate appropriations committee is doing its markups of the various funding bills (which all technically originated in the House), and it appears that they have pushed to keep the funding for NASA and NSF (which are bundled in the same bill with the Department of Justice for no obvious reason) at FY24 levels. See here as well. This is not yet a done deal within the Senate, but it's better than many alternatives. If you are a US citizen or permanent resident and one of your senators is on the appropriations committee, please consider calling them to reinforce how devastating massive budget cuts to these agencies would be. I am told that feedback to any other senators is also valuable, but appropriators are particularly important here. The House appropriations committee has not yet met to mark up their versions. They had been scheduled to do so earlier this week but punted it for an unknown time. Their relevant subcommittee membership is here. Again, if you are a constituent of one of these representatives, your calls would be particularly important, though it doesn't hurt for anyone to make their views heard to their representative. If the House version aligns with the presidential budget request, then a compromise between the two might still lead to 30% cuts to NSF and NASA, which would (IMO) still be catastrophic for the agencies and US science and competitiveness. This is a marathon, not a sprint. There are still many looming difficulties - staffing cuts are well underway. Spending of already appropriated funds at agencies like NSF is way down, leading to the possibility that the executive branch may just order (or not-order-but-effectively-order) agencies not to spend and then claw back the funds. This year and in future years they could decide to underspend appropriations knowing that any legal resistance will take years and cost a fortune to work its way through the courts. This appropriations battle is also an annual affair - even if the cuts are forestalled for now (it is unlikely that the executive would veto all the spending bills over science agency cuts), this would have to happen again next year, and so on. Still, right now, there is an opportunity to push against funding cuts. Failing to try would be a surrender. (Obligatory notice: yes, I know that there are large-scale budgetary challenges facing the US; I don't think destroying government investment in science and engineering research is an intelligent set of spending cuts.)
For the first time, solar was the largest source of electricity in the EU last month, supplying a record 22 percent of the bloc's power. Read more on E360 →
Episode two of The Works in Progress Podcast is out now
Calling all the builders
