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Introduction Proteins are nature's versatile nanomachines— they have evolved to perform virtually every important task in living systems. While nature has produced an incredible range of protein functions, these represent only a tiny fraction of what's possible in the protein universe. Evolution has only explored
7 months ago

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More from Apoorva Srinivasan

a review on protein language models

Protein “language” is a lot like human language. Given the similarities, researchers have been building and training language models on protein sequence data, replicating the success seen in other domains, with profound implications. In this post, I will explore how transformer models have been applied to protein data

a year ago 37 votes
an experiment in navigating the knowledge frontier beyond search

Lately, I've been experimenting with interfaces for large language models (LLMs) in my free time. The fruit of this labor is something I'm calling "curie," an exploratory and sense-making tool designed to navigate complex topics. 0:00 0:34 1× the limitations of

a year ago 28 votes
what's happened since the human genome project

When the human genome project was deemed “complete” in 2003, it was met with incredible fanfare. The entire project leading up to that moment had all the drama to keep its audience enthralled. Fierce rivalry between a public and private institution, multiple countries involved, 3.5 billion dollars

over a year ago 27 votes
niceR code with functional programming

At the end of this blog post, you will be able to: Describe functional programming concepts Write functional programming code using purrr package in R If you are anything like me, you probably focused primarily on learning statistics, machine learning and programming on a smaller scale early on in your

over a year ago 28 votes

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China's most overrated asset with Mike Bird

Episode four of the Works in Progress podcast is about land.

17 hours ago 5 votes
New Physics-Inspired Proof Probes the Borders of Disorder

For decades, mathematicians have struggled to understand matrices that reflect both order and randomness, like those that model semiconductors. A new method could change that. The post New Physics-Inspired Proof Probes the Borders of Disorder first appeared on Quanta Magazine

17 hours ago 2 votes
How Should We Evaluate Healthcare AI? Some Thoughts | Out-Of-Pocket

Maybe we’re thinking about all of these papers the wrong way

3 days ago 5 votes
The Amazon Rainforest Approaches a Point of No Return

In “Amazon Tipping Point” — Third-Place Winner of the 2025 Yale Environment 360 Film Contest — Brazilian filmmakers capture striking images of clear-cutting and explore how human activity is so damaging the world’s largest rainforest that it will not be able to recover. Read more on E360 →

4 days ago 5 votes
Lithium and Alzheimer’s Disease

This is an interesting story, and I am trying to moderate my optimism. Alzheimer’s disease (AD), the major cause of dementia in humans, is a very complex disease. We have been studying it for decades, revealing numerous clues as to what kicks it off, what causes it to progress, and how to potentially treat it. […] The post Lithium and Alzheimer’s Disease first appeared on NeuroLogica Blog.

4 days ago 6 votes