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When the human genome project was deemed “complete” in 2003, it was met with incredible fanfare. The entire project leading up to that moment had all the drama to keep its audience enthralled. Fierce rivalry between a public and private institution, multiple countries involved, 3.5 billion dollars
over a year ago

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More from Apoorva Srinivasan

diffusion models for protein generation

Introduction Proteins are nature's versatile nanomachines— they have evolved to perform virtually every important task in living systems. While nature has produced an incredible range of protein functions, these represent only a tiny fraction of what's possible in the protein universe. Evolution has only explored

8 months ago 76 votes
a review on protein language models

Protein “language” is a lot like human language. Given the similarities, researchers have been building and training language models on protein sequence data, replicating the success seen in other domains, with profound implications. In this post, I will explore how transformer models have been applied to protein data

a year ago 41 votes
an experiment in navigating the knowledge frontier beyond search

Lately, I've been experimenting with interfaces for large language models (LLMs) in my free time. The fruit of this labor is something I'm calling "curie," an exploratory and sense-making tool designed to navigate complex topics. 0:00 0:34 1× the limitations of

a year ago 31 votes
niceR code with functional programming

At the end of this blog post, you will be able to: Describe functional programming concepts Write functional programming code using purrr package in R If you are anything like me, you probably focused primarily on learning statistics, machine learning and programming on a smaller scale early on in your

over a year ago 30 votes

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How to discover competitors' pricing, the legal way | Out-Of-Pocket

Please don’t ask me about the illegal way…I’m not telling you

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Magical systems thinking

Systems thinkers fail because they ignore an important fact: systems fight back.

15 hours ago 3 votes
A Single, ‘Naked’ Black Hole Rewrites the History of the Universe

The James Webb Space Telescope has found a lonely black hole in the early universe that’s as heavy as 50 million suns. A major discovery, the object confounds theories of the young cosmos. The post A Single, ‘Naked’ Black Hole Rewrites the History of the Universe first appeared on Quanta Magazine

12 hours ago 2 votes
DOE Experimental Condensed Matter Physics PI Meeting 2025 - Day 3 and wrap-up

A few more interesting tidbits from the concluding half-day of the DOE ECMP PI meeting: Dmitri Basov showed some of the remarkable experiments enabled by layers of MoOCl2, which in the IR is an intrinsically hyperbolic optical material.  This material has unusual plasmonic properties considering its high resistivity.  These include peculiar cavity effects such as modifying superfluid density of a proximally coupled superconductor. Leonid Butov explained some remarkable evidence for superfluidity of indirect excitons excited in the moire bilayer of MoSe2/WSe2.  Low temperature mean free paths of these objects can exceed hundreds of microns (!). Cui-Zu Chang showed evidence that truly stoichiometric FeTe is actually a superconductor with a critical temperature of about 13.5 K, rather than the usual thinking that it is an antiferromagnetic metal. Apparently an extra 2% of interstitial iron is enough to kill superconductivity and induce AFM order. James McIver presented an example of how nonlinear optical effects in an optically driven (Floquet) Weyl semimetal seem to vary linearly with driving field - anomalously strong. Dmytro Bozhko showed a really neat technique, using Brillouin light scattering to map out the dispersion of phonons and magnons in YIG, and to extend this approach with a special hollow-core optical fiber to low temperatures with the motivation of probing magnon superfluidity in a particular antiferromagnetic insulator. Ray Ashoori used his characteristically pretty quantum capacitance measurement technique to examine the density+displacement field+magnetic field phase diagram of 5-layer rhombohedral graphene, revealing some surprising fractional Chern insulator states. Claudia Ojeda-Aristizabal discussed some mesoscopic transport measurements in bilayer graphene, where an adsorbed layer of spin-containing CuPc molecules seems to affect both decoherence and the trigonal warping contribution to it (related to intervalley scattering).  Feng Wang and You Zhou both discussed recent measurements looking at Wigner crystals and their properties in 2D TMDs, through a variety of means. Liuyan Zhao showed some very rich physics obtained in studies that moiré stack bilayers of the van der Waals insulating magnet CrI3.   Unfortunately I missed the last talk because of the need to head to the airport.  Overall, the meeting was very good.  Program PI meetings can tend to become less about telling coherent scientific stories and more about trying to show everything someone has done in the last three years.  This meeting avoided that, with clear talks that generally focused on one main result, and that made it much more engaging.  As good as tools for virtual gatherings have become, there really is no substitute for an in-person event when you can just talk to someone by the coffee about some new idea.

2 days ago 3 votes
A Pollution Paradox: Western Wildfires Improve Air Quality on the East Coast

Western wildfires are producing massive plumes of smoke that have, in recent years, clouded eastern skies. But a new study finds that, paradoxically, heat from fires is reshaping weather patterns in ways that are actually improving overall air quality on the East Coast. Read more on E360 →

2 days ago 3 votes