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Anti-aging tech fixes demographic collapse

from Casey Handmer's blog [alt+shift+b] in science

With the latest studies on GLP-1 drugs showing not just a drop in all-cause mortality but also an apparent slowing of aging, I thought I’d write a quick note on how I think this technology, if it replicates, can drastically improve our lives. It’s hard to believe I’m writing this, but I think the ability to achieve immortality is underrated. To a good approximation, nearly all our illness and healthcare burden is aging-related. Hospitals rarely contain 20 year old people, who rarely get sick and generally recover quickly when they do. Heart disease, kidney failure, Alzheimer’s, cancer, respiratory failure, stroke, …
2nd Sep 2024

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More from Casey Handmer's blog

How deep is Tulainyo Lake?

Regular readers may recall that I put a visit to Tulainyo Lake on my bucket list a few years ago. Last week I did it. Impossibly remote, otherworldly beauty, and an enduring mystery. Just how deep was this lake? Wikipedia claims not to know. Measuring it is non-trivial. A worthy challenge. The skinny: This relatively small alpine lake is about 117 m deep! That makes it the 25th deepest natural lake in North America, and by far the deepest lake on Earth for its size. Enjoy our interactive report here.

2 weeks ago • 1 votes
How to build a crazy awesome Australian immigration system

The Australian immigration system must exclude dickheads, bullshitters, and bludgers. This post has been inspired by Joe Walker’s recent set of three exemplary interviews (Martin Parkinson (former Treasury, author of 2023 migration review), Mark Cully (historian), Mike Pezzullo (senior border official 2013-2023))  on the subject of immigration policy. This comes against a backdrop of growing scepticism within the West on current levels of immigration, concerns about integration, cultural compatibility, rising costs of living, straining public services and infrastructure, and the rapidly increasing popularity of hardline anti-immigration political parties who, in some cases, have already won defining majorities within the Western …

10th Jun 2026 • 2 votes
How to build a lunar mass driver

Casey Handmer May 2026 What? Elon has recently (late 2025, early 2026) been talking about building many terawatts of orbital AI compute and launching some components from Moon factories with a mass driver. This is an old idea, enabled by …

8th May 2026 • 1 votes
Australia will run an overt command economy by 2040

Australia’s Fiscal Point of No Return Last September I wrote about Australian economic stagnation — how taxation past the Laffer curve’s point of peak growth, zero public sector productivity improvement since 2001, and the systematic eradication of manufacturing and ICT from the economy have combined to produce economic stagnation and flatlining living standards. The NDIS and similar social spending were the only parts of the economy “growing,” but because this spending is not cumulatively generative, it’s not able to sustain long term high quality public benefits. In other words, we’re burning the seed corn. The post generated a question I …

16th Apr 2026 • 1 votes
Notes on the Fermi Paradox

I recently realized I hadn’t written much in this blog about the Fermi Paradox, though I do write about it elsewhere. So here is a quick note. The Fermi Paradox, sometimes paraphrased as “where are they?” is a question about the apparent lack of intelligent alien life in the universe. The universe is extreme old relative to the speed of light at galactic scales. Light has been able to cross our galaxy a thousand times since the dinosaurs died out, and that was relatively recent (less than 2%) compared to the age of the Earth. So if life is common …

3rd Mar 2026 • 1 votes

More in science

370 | Daniel Akerib on a Faint Hint of Dark Matter

One reason it's been so hard to directly detect the dark matter is that we're not sure what it is. […]

4 hours ago • 1 votes
The arXiv - where it's been and where it's going

Back in the ancient mists of time, scientists and mathematicians would circulate preprints of their articles among friends and colleagues via the postal service, as a courtesy, to get feedback and to try to make sure people in the community were aware of their forthcoming work.  As the wikipedia entry says, with the advent of widespread LaTeX and the development of the web, Paul Ginsparg (then at LANL) put together an html-based site for electronic sharing of preprints, initially at xxx.lanl.gov (back before "xxx" in URLs was the kind of thing filtered and blocked by employers).   In 2001 he moved to Cornell, and by then the lab was perhaps relieved to see the site, rebranded as the arXiv, shift to Cornell's library/repository infrastructure.   PIs my age remember (fondly? maybe?) the old days of the arXiv, when Prof. Ginsparg's rather dry sense of humor pervaded the site.  The skull-and-crossbones logo.  The "help"/FAQ pages that basically said, "if you can't figure out how to .tar.gz all of your necessary LaTeX files, and you can't figure out how to make your .eps figures small, maybe you should reconsider whether you're smart enough to be sharing your ideas here".  The arXiv was for preprints, without peer review (though interesting follow-on sites like Scirate now exist for organized commenting on the articles). From these modest beginnings, the arXiv has grown enormously, including imitators/spin-offs such as chemrxiv and biorXiv and socarXiv.  The arXiv has recently become an independent nonprofit, hired a CEO, secured multiyear philanthropic support, and hosts over 3 million articles.  It's been interesting seeing some level of complaints online about some of these steps, but when the audience is so large, not everyone is going to be happy.  Rapid growth has been a major issue - see here for a graph of monthly submissions: The exponential rise (except for a slight pandemic-correlated shoulder) has been problematic, especially recently.  One hallmark of the arXiv over the years has been its ability to function with comparatively minimal need for "moderation".  Early on, one consequence of the minimalistic help and moderate technical entry barrier was that it was unusual for fringe/pseudoscience to make its way onto the server.  (Hence the establishment of viXra.)  With the ease of cranking out properly formatted readable manuscripts using AI, clearly the arXiv has been struggling.  If 10-15% of submissions need some kind of human intervention or review, the support needs are rapidly outpacing the limited count of support staff.  There can be substantial backlogs.  To help deal with this, the arXiv recently updated its policies regarding AI-generated content (and AI cannot be a co-author, because the AI tools cannot take responsibility for content), and most recently has had to limit submission rates to two papers per month per submitting author.  These moves, too, have drawn some criticism (e.g. here).  Personally, I think the operators of the arXiv face an incredibly challenging environment and are doing the best they can - the idea that they are making moves because they are establishment sticks in the mud who don't understand the New Way of Doing Science is just wrong-headed. It's completely unclear where all this is heading.  Exponential growth in nature signals instability and does not continue forever. If proponents of very heavily AI-driven research want to establish a repository specifically for that work, that's up to them.  [It is very on brand for the hard core AI advocates to argue that the arXiv is somehow morally obligated to host everything (regardless of hardware or personnel costs) so that future AI tools can read everything (a repository growing too quickly for human researchers to keep up) and summarize it.] One overarching point that should come up in any arXiv discussion: The arXiv has become a global repository for an enormous amount of human knowledge, without charging anyone publication fees.  This should make interested parties think reallllllly hard about economic models of for-profit publishers.

20 hours ago • 1 votes
Haunted by the ghosts of materialism

Is philosophy real? We sent our correspondent to find out.

2 days ago • 1 votes
Butterflies Are Masters of Illusion

Stephen J Gould (still my favorite science essayist) wrote an excellent article in 1985 (Red Wings in the Sunset, later published in his book, Bully for Brontosaurus) about artist and naturalist Abbott Handerson Thayer. Thayer wrote about how animals use coloration as camouflage – what he called “cryptic coloration”. His ideas were solid, but he made a classic mistake that scientists sometimes make, overapplying their key discovery. Thayer argued that all animal coloration is cryptic. For example, he argued that flamingos are pink because it hides them in the setting sun (hence the title of the essay). This is a transparently absurd argument, and it shows how Thayer tried to shoehorn all evidence into his preferred and absolute narrative. It is better to assume that nature is complex, and all explanations are at best partial (unless proven otherwise). Animal coloration, in fact, can serve many different purposes, only one of which is camouflage. Thayer also struggled with the male peacock, for example. Butterflies appear to be another example. Actually, many butterflies are camouflaged on the underside of their wings, so that when they are at rest with their wings up they tend to blend into their surroundings. But the top side of their wings are often very colorful and not camouflaged at all. One assumption is that the brightly colored part of their wings is to attract mates. This may be true, but that does not mean the coloration does not serve another function. Often animals use visual cues when choosing their mates that are markers for health and success. As evidence that butterfly wing color may be serving a survival benefit, if you look at birds that feed on insects during flight, they target dully-colored moths much more than brightly colored butterflies, even though the butterflies should be easier to see. A recent study tests the hypothesis that the brightly colored and patterned top side of butterfly wings may have evolved to produce an optical illusion to confuse predators. The idea of using optical illusions as visual protection in animals is not new. For example, zebra stripes allow zebras to hide in the herd, confusing predators as to where one zebra ends and another begins. Stripes on zebras and snakes may also serve to confuses predators about their direction of motion, but this hypothesis has not been tested previously. The researchers started by filming butterflies taking off using high speed cameras. They found that the wing patterns created a powerful “barber pole” illusion. The stripes on a barber pole look like they are moving up or town even when the pole is just spinning. Similarly, the wing patterns combined with the way butterflies move their wings and their flight dynamics combine to create a similar barber pole illusion, making the butterfly look like it is moving down when it is in fact moving up. They also showed that this strategy is phylogenetically widespread. They then did modeling in silico and showed digital creatures converge on butterfly-like patterns. To understand how effective this strategy can be it’s important to understand how catching a butterfly in midflight works. Butterflies have a very jumpy pattern of flight. In order to grab them in flight, a bird will have to zero in on their exact location with a few hundred millisecond and millimeter precision. If the butterfly suddenly zigs while the bird perceives that they zagged, the birdy will miss. Alternatively they may make only a glancing blow or grab an edge of a wing rather than their body. Either way, the butterfly lives another day and the bird goes hungry. In zebras this effect has been referred to as the “visual dazzle” strategy. Now there is some empiric evidence that this works not just by confusing predators, but by creating a specific optical illusion. Zebras will also zig-zag to evade predators, and misjudging that last second movement can cause a pouncing lioness to miss. There are two specific illusion effects at work – the aperture effect and spatiotemporal aliasing. The aperture effect refers to the brain’s processing of visual information through a limited field of view. The visual system has a hard time processing many moving stripes, and specifically will confuse the direction of movement (this is the barber pole effect). So a predator may miss a zebra’s vertical movement, for example, and perceive all movement as perpendicular to the stripes. They may also misinterpret the angle of movement and only perceive the perpendicular motion. Spatiotemporal aliasing has to do with ratio of the movement with the “refresh” speed of the brain’s visual processing. You have likely seen this with spinning wheels that have spoke-like features. As the wheel slows down, at one point the spinning will appear to stop completely, and then will appear to spin backwards. This is simply an artifact of your brain’s visual processing speed. Now imagine being surrounded by a field of rapidly moving and zig-zagging stripes, and your brain trying to make sense of all this information, while trying to compensate for these powerful optical illusions. Butterflies don’t have a herd to hide in, but they do have the added element of their flapping wings. Not only are they moving in a way to maximize these optical illusions, their wings are also doing this, while alternating top-side and bottom-side. Some butterflies have bright spots on their colorful upper wings, that will flash as they flap their wings, causing another type of dazzling disorientation. I will end by returning to my original point – do not be limited in the types of explanations that you reach for when trying to understand nature. Nature is not so limited. Animals do not just use coloration for camouflage and attracting mates. They can also use their coloring for thermoregulation, for mimicking other animals, for producing a danger-signal to would-be predators, and to communicate with other members of their species. It can communicate mood, danger, or social status. Now we have to add optical illusions to the list. There may be other strategies yet to be discovered or imagined. The post Butterflies Are Masters of Illusion first appeared on NeuroLogica Blog.

4 days ago • 1 votes
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